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Random walk and gap plots of DNA sequences

机译:DNA序列的随机游动图和缺口图

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摘要

Genomic sequence analysis is usually performed with the help of specialized software packages written for molecular biologists. The scope of such pre-programmed techniques is quite limited. Because DNA sequences contain a large amount of information, analysis of such sequences without underlying assumptions may provide additional insights. The present article proposes two new graphical representations as examples of such methods. The random walk plot is designed to show the base composition in a compact form, whereas the gap plot visualizes positional correlations. The random walk plot represents the DNA sequence as a curve, a random walk, in a plane. The four possible moves, left/right and up/down, are used to encode the four possible bases. Gap plots provide a tool to exhibit various features in a sequence. They visualize the periodic patterns within a sequence, both with regard to a single type of base or between two types of bases
机译:基因组序列分析通常在为分子生物学家编写的专用软件包的帮助下进行。这种预编程技术的范围非常有限。由于DNA序列包含大量信息,因此无需基础假设即可对此类序列进行分析可能会提供其他见解。本文提出了两种新的图形表示形式作为此类方法的示例。设计随机游动图以紧凑形式显示基本组成,而间隙图则可视化位置相关性。随机游动图将DNA序列表示为平面中的曲线,随机游动。左/右和上/下四个可能的移动用于编码四个可能的基准。间隙图提供了一种工具来展示序列中的各种特征。它们使序列中的周期模式可视化,无论是关于单一类型的碱基还是在两种类型的碱基之间

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